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Contraindicated (one)pentobarbital will lessen the extent or influence of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is answerable for the formation and elimination of cariprazine's Lively metabolites.pentobarbital will reduce the level or impact of ibuprofen by affecting hepatic enzyme CYP2C9/ten